PT-141 10 mg reconstitution and dosage chart
The 10 mg vial at four water volumes, every dose from 0.5 to 2 mg converted to the mark on a U-100 syringe, with how many uses a vial holds.
25 printable pages: dosing cards for the twelve most-used compounds at three water volumes, titration planners, a vial log, and five pages on what to do when it has already gone wrong.
How to reconstitute a 10 mg PT-141 vial
Add 2 mL of bacteriostatic water to the 10 mg vial, run it down the glass wall rather than onto the powder, and swirl gently until it is clear; do not shake. That makes 5 mg/mL, so 1 mg is 20 units on a U-100 insulin syringe, 0.5 mg is 10 units and the licensed 1.75 mg is 35 units. With 1 mL of water the same three doses are 10, 5 and 17.5 units. Once mixed, keep the vial in the fridge, never the freezer, and use it within about four weeks.
PT-141 is bremelanotide. It is a licensed medicine (Vyleesi) at 1.75 mg by subcutaneous autoinjector, with a limit of one dose in 24 hours and eight a month; research vials of 10 mg are sold outside that licence and are not the licensed product. It is dosed as needed rather than on a schedule, an hour or two before, which makes the per-dose number matter more here than the weekly total.
10 mg vial
| BAC water | Concentration | 0.5 mg | 0.75 mg | 1 mg | 1.5 mg | 1.75 mg | 2 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 10 mg/mL | 5 | 7.5 | 10 | 15 | 17.5 | 20 |
| 2 mL | 5 mg/mL | 10 | 15 | 20 | 30 | 35 | 40 |
| 3 mL | 3.33 mg/mL | 15 | 22.5 | 30 | 45 | 52.5 | 60 |
| 4 mL | 2.5 mg/mL | 20 | 30 | 40 | 60 | 70 | 80 |
Units on a standard U-100 insulin syringe. * means more than 100 units, so more than one 1 mL syringe.
How many units is 1 mg of PT-141?
20 units from a 10 mg vial reconstituted with 2 mL of bacteriostatic water, which is 5 mg/mL and makes 1 mg a 0.2 mL draw. The licensed 1.75 mg is 35 units at that setup. With 1 mL of water both halve, to 10 and 17.5 units.
10 mg in 2 mL, dose by dose
| Dose | Draw | U-100 units | Uses per vial |
|---|---|---|---|
| 0.5 mg | 0.1 mL | 10 units | 20 |
| 0.75 mg | 0.15 mL | 15 units | 13 |
| 1 mg | 0.2 mL | 20 units | 10 |
| 1.5 mg | 0.3 mL | 30 units | 6 |
| 1.75 mg | 0.35 mL | 35 units | 5 |
| 2 mg | 0.4 mL | 40 units | 5 |
Frequency, and how far a vial goes
PT-141 is taken as needed, not daily. The licensed product caps use at one dose in 24 hours and eight doses in a month. A 10 mg vial at 1 mg a time is 10 uses; at the licensed 1.75 mg it is 5, which at the eight-a-month ceiling is most of a month either way. Nausea is the most reported side effect and it scales with the dose, which is why reports commonly describe starting at the low end of the range rather than the licensed figure.
| Dose | U-100 units | Uses per 10 mg vial | At the licensed ceiling | At half that |
|---|---|---|---|---|
| 0.5 mg | 10 units | 20 | 2.5 months at 8 a month | 5 months at 4 a month |
| 1 mg | 20 units | 10 | 1.2 months at 8 a month | 2.5 months at 4 a month |
| 1.5 mg | 30 units | 6 | 0.8 months at 8 a month | 1.5 months at 4 a month |
| 1.75 mg | 35 units | 5 | 0.6 months at 8 a month | 1.2 months at 4 a month |
| 2 mg | 40 units | 5 | 0.6 months at 8 a month | 1.2 months at 4 a month |
Timing, and why the half-life matters more than the units
The half-life is about 2.7 hours, from the licensed product label. The licensed product is taken at least 45 minutes before; reports commonly describe one to two hours. Because it clears the same day there is no build-up between uses and nothing left over by the next one, which is the practical difference between an as-needed compound and a daily one: the vial maths is about how many uses you get, not about weeks of supply.
It raises blood pressure transiently, and the licence excludes people with uncontrolled hypertension. Whether any of this applies to you is a question for a clinician, not for a conversion table.
Common questions
- How do I reconstitute a 10 mg PT-141 vial?
- Add 2 mL of bacteriostatic water, run it down the glass wall and swirl gently until clear. That gives 5 mg/mL, so 1 mg is 20 units on a U-100 syringe and the licensed 1.75 mg is 35 units. Keep the mixed vial in the fridge and use it within about four weeks.
- How many units is 1 mg of PT-141?
- 20 units from a 10 mg vial reconstituted with 2 mL of bacteriostatic water, which is 5 mg/mL. The licensed 1.75 mg dose is 35 units at that setup. With 1 mL of water both halve, to 10 and 17.5 units.
- How much bacteriostatic water for a 10 mg PT-141 vial?
- 2 mL is the usual choice and gives 5 mg/mL, which puts the 0.5 to 2 mg range at 10 to 40 units. With 1 mL that range is 5 to 20 units, which is tighter to read but stretches the vial no further.
- How many doses are in a 10 mg PT-141 vial?
- Ten at 1 mg, five at 2 mg, and five at the licensed 1.75 mg. The licensed product caps use at one dose in 24 hours and eight in a month.
- Can I inject a full 10 mg vial of PT-141 at once?
- A 10 mg vial is the whole supply, not one dose. At 5 mg/mL a full vial is 2 mL, which is 200 units or two full syringes, and it is five to ten times the 1 to 2 mg range these charts cover and more than five times the licensed 1.75 mg dose. Doses are drawn from the vial a measured amount at a time, and the table shows the mark for each.
- How long before does PT-141 need to be taken?
- The licensed product is taken at least 45 minutes before. Reports commonly describe one to two hours. The half-life is about 2.7 hours, so it clears the same day and does not build up between uses.
- Is research PT-141 the same as Vyleesi?
- No. Vyleesi is a licensed autoinjector at a set 1.75 mg strength with its own quality control. Research vials are sold outside that licence, are not approved for human use, and are not interchangeable with it.
Common conversions
The same three-step maths, pre-filled for the doses people ask about most. Units on a U-100 insulin syringe, where 100 units is 1 mL.
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