Semaglutide titration schedule
The whole ladder, converted into the exact number of units to draw at every stage. Change the vial or the water and it recalculates.
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ReviewedDose ranges and half-life figures last checked 3 September 2026.
The schedule
| Stage | Weekly dose | Draw | U-100 units | Vials used by end |
|---|---|---|---|---|
| Weeks 1–4 | 0.25 mg | 0.1 mL | 10 units | 0.2 |
| Weeks 5–8 | 0.5 mg | 0.2 mL | 20 units | 0.6 |
| Weeks 9–12 | 1 mg | 0.4 mL | 40 units | 1.4 |
| Weeks 13–16 | 1.7 mg | 0.68 mL | 68 units | 2.8 |
| Weeks 17–20 | 2.4 mg | 0.96 mL | 96 units | 4.7 |
Based on a 5 mg vial with 2 mL of bacteriostatic water (2.5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.
How to read it
Semaglutide has a licensed ladder: 0.25 mg weekly for four weeks, then 0.5 mg, 1.0 mg, 1.7 mg and 2.4 mg, each held for four weeks before the next step. As with tirzepatide, the first rung is a starting dose for tolerance rather than a maintenance dose.
The doses are small enough that the water volume matters more here than for any other compound. A 5 mg vial in 2 mL puts 0.25 mg at 10 units. The same vial in 1 mL puts it at 5 units, where a one-unit misread is a 20 percent dosing error.
A titration ladder is a maximum pace, not a target. Holding at a lower dose for longer is a normal outcome, not a failure.
Common questions
- What is the standard semaglutide titration schedule?
- 0.25 mg once weekly for four weeks, then 0.5 mg, 1.0 mg, 1.7 mg and 2.4 mg, stepping every four weeks as tolerated.
- How many units is 0.25 mg of semaglutide?
- In a 5 mg vial with 2 mL of bacteriostatic water, which is 2.5 mg/mL, 0.25 mg is 0.1 mL, or 10 units on a U-100 syringe.
- What if a step is intolerable?
- The licensed guidance is to hold at the previous dose for longer rather than push through. The ladder is a maximum pace, not a schedule you owe anyone.
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Read this before you use the numbers. This is a unit-conversion tool. It converts a vial strength and a volume of bacteriostatic water into a concentration, a draw volume and a mark on an insulin syringe. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most of the compounds listed here are sold for laboratory research use and are not approved for human use. Nothing on this site is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always confirm the strength printed on your own vial rather than trusting a preset.