How long does a full retatrutide titration take?

Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.

How many vials do I need for a full titration?

At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.

Do I have to reach 12 mg?

No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.

Retatrutide titration schedule

Every stage of the 2 mg to 12 mg ladder, in units to draw. Use the calculator for your own vial and water.

Reviewed 3 September 2026
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ReviewedDose ranges and half-lives checked 3 September 2026.

The schedule

Stage	Weekly dose	Draw	U-100 units	Vials used by end
Weeks 1–4	2 mg	0.4 mL	40 units	0.8
Weeks 5–8	4 mg	0.8 mL	80 units	2.4
Weeks 9–12	6 mg	1.2 mL	120 units	4.8
Weeks 13–16	8 mg	1.6 mL	160 units	8.0
Weeks 17–20	10 mg	2 mL	200 units	12.0
Weeks 21–24	12 mg	2.4 mL	240 units	16.8

Based on a 10 mg vial with 2 mL of bacteriostatic water (5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.

How to read it

Retatrutide is investigational and has no licensed titration schedule, because it has never been approved. The ladder below is the pattern most commonly reported: start at 2 mg weekly and step up 2 mg every four weeks. Some people step every six or eight weeks instead, and plenty stop well before 12 mg.

The point of a slow ladder is tolerability. Stepping faster than your side effects allow is the single most common reason people abandon a GLP-1 entirely.

A titration ladder is a maximum pace, not a target. Holding at a lower dose for longer is a normal outcome, not a failure.

Common questions

How long does a full retatrutide titration take?: Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.
How many vials do I need for a full titration?: At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.
Do I have to reach 12 mg?: No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.

MethodologyEvery formula and rounding rule, so you can check the maths Read a syringeU-100 vs U-40, and the 2.5x error Build a full protocolThe stack builder at Peptide Bureau, about two minutes

Common conversions

The same three-step maths, pre-filled for the doses people ask about most. Units on a U-100 insulin syringe, where 100 units is 1 mL.

mg to units calculator Any dose at any concentration, both directions, with the full reference tables
Units to mg calculator What the units you drew are in milligrams
1 mg to units The most-asked conversion, at every common setup

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Every one of the 27 compound calculators, charts and tools: the full list.

Before you use these numbers This is a unit-conversion tool. It turns a vial strength and a water volume into a concentration, a draw volume and a syringe mark. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most compounds listed are sold for laboratory research and are not approved for human use. Nothing here is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always check the strength printed on your own vial rather than trusting a preset.