Retatrutide titration schedule
The whole ladder, converted into the exact number of units to draw at every stage. Change the vial or the water and it recalculates.
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The maths is openThe formula is written out on this page and the code behind it is a single
file with an automated test suite .
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Never inside the calculator.
ReviewedDose ranges and half-life figures last checked 3 September 2026.
The schedule
| Stage | Weekly dose | Draw | U-100 units | Vials used by end |
|---|---|---|---|---|
| Weeks 1–4 | 2 mg | 0.4 mL | 40 units | 0.8 |
| Weeks 5–8 | 4 mg | 0.8 mL | 80 units | 2.4 |
| Weeks 9–12 | 6 mg | 1.2 mL | 120 units | 4.8 |
| Weeks 13–16 | 8 mg | 1.6 mL | 160 units | 8.0 |
| Weeks 17–20 | 10 mg | 2 mL | 200 units | 12.0 |
| Weeks 21–24 | 12 mg | 2.4 mL | 240 units | 16.8 |
Based on a 10 mg vial with 2 mL of bacteriostatic water (5 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.
How to read it
Retatrutide is investigational and has no licensed titration schedule, because it has never been approved. The ladder below is the pattern most commonly reported: start at 2 mg weekly and step up 2 mg every four weeks. Some people step every six or eight weeks instead, and plenty stop well before 12 mg.
The point of a slow ladder is tolerability. Stepping faster than your side effects allow is the single most common reason people abandon a GLP-1 entirely.
A titration ladder is a maximum pace, not a target. Holding at a lower dose for longer is a normal outcome, not a failure.
Common questions
- How long does a full retatrutide titration take?
- Stepping 2 mg every four weeks from 2 mg to 12 mg is six stages, which is 24 weeks. Slower steps of six weeks make it 36 weeks.
- How many vials do I need for a full titration?
- At a 10 mg vial, stepping 2 mg every four weeks to 12 mg, the whole ladder uses about 16.8 vials. The early stages are cheap and the top of the ladder is where the cost sits.
- Do I have to reach 12 mg?
- No. The ladder is a ceiling, not a target. Many reported protocols hold at 4, 6 or 8 mg indefinitely.
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Tools
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Read this before you use the numbers. This is a unit-conversion tool. It converts a vial strength and a volume of bacteriostatic water into a concentration, a draw volume and a mark on an insulin syringe. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most of the compounds listed here are sold for laboratory research use and are not approved for human use. Nothing on this site is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always confirm the strength printed on your own vial rather than trusting a preset.