What is the standard tirzepatide titration schedule?

2.5 mg once weekly for four weeks, then 5 mg for four weeks, then increases of 2.5 mg every four weeks as tolerated, up to a maximum of 15 mg weekly.

How many units is each step?

It depends on your concentration. In a 30 mg vial with 3 mL of water, which is 10 mg/mL, the ladder runs 25, 50, 75, 100, 125 and 150 units. The last two exceed a 1 mL syringe, so use less water if you are going high.

Can I skip the 2.5 mg stage?

The starting dose exists to build tolerance to gastrointestinal side effects. Skipping it is the usual reason people find the drug intolerable and stop.

Tirzepatide titration schedule

Every stage of the 2.5 mg to 15 mg ladder, in units to draw. Use the calculator for your own vial and water.

Reviewed 3 September 2026
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ReviewedDose ranges and half-lives checked 3 September 2026.

The schedule

Stage	Weekly dose	Draw	U-100 units	Vials used by end
Weeks 1–4	2.5 mg	0.25 mL	25 units	0.3
Weeks 5–8	5 mg	0.5 mL	50 units	1.0
Weeks 9–12	7.5 mg	0.75 mL	75 units	2.0
Weeks 13–16	10 mg	1 mL	100 units	3.3
Weeks 17–20	12.5 mg	1.25 mL	125 units	5.0
Weeks 21–24	15 mg	1.5 mL	150 units	7.0

Based on a 30 mg vial with 3 mL of bacteriostatic water (10 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.

How to read it

Tirzepatide has a licensed titration ladder, which makes it the most clearly defined schedule on this site: 2.5 mg weekly for four weeks, then 5 mg, then steps of 2.5 mg every four weeks up to a maximum of 15 mg. The 2.5 mg stage is a starting dose intended to build tolerance, not a maintenance dose.

The licensed product is a pre-filled pen at a fixed concentration. If you reconstitute a vial yourself you choose the concentration, so unit counts quoted for a pen will not match your own.

A titration ladder is a maximum pace, not a target. Holding at a lower dose for longer is a normal outcome, not a failure.

Common questions

What is the standard tirzepatide titration schedule?: 2.5 mg once weekly for four weeks, then 5 mg for four weeks, then increases of 2.5 mg every four weeks as tolerated, up to a maximum of 15 mg weekly.
How many units is each step?: It depends on your concentration. In a 30 mg vial with 3 mL of water, which is 10 mg/mL, the ladder runs 25, 50, 75, 100, 125 and 150 units. The last two exceed a 1 mL syringe, so use less water if you are going high.
Can I skip the 2.5 mg stage?: The starting dose exists to build tolerance to gastrointestinal side effects. Skipping it is the usual reason people find the drug intolerable and stop.

MethodologyEvery formula and rounding rule, so you can check the maths Read a syringeU-100 vs U-40, and the 2.5x error Build a full protocolThe stack builder at Peptide Bureau, about two minutes

Common conversions

The same three-step maths, pre-filled for the doses people ask about most. Units on a U-100 insulin syringe, where 100 units is 1 mL.

mg to units calculator Any dose at any concentration, both directions, with the full reference tables
Units to mg calculator What the units you drew are in milligrams
1 mg to units The most-asked conversion, at every common setup

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Every one of the 27 compound calculators, charts and tools: the full list.

Before you use these numbers This is a unit-conversion tool. It turns a vial strength and a water volume into a concentration, a draw volume and a syringe mark. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most compounds listed are sold for laboratory research and are not approved for human use. Nothing here is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always check the strength printed on your own vial rather than trusting a preset.