Tirzepatide reconstitution chart
Six vial sizes, four water volumes, the concentration of each combination and the units for every rung of the 2.5 to 15 mg ladder.
Tirzepatide vials come in 5, 10, 15, 20, 30 and 60 mg. The water you add sets the concentration, and the concentration sets how many units each rung of the 2.5 to 15 mg ladder needs. This chart gives every combination so you can pick a water volume that keeps your dose readable and inside one syringe.
Concentration for every vial and water volume
| Vial | 1 mL | 2 mL | 3 mL | 4 mL |
|---|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL | 1.25 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL | 2.5 mg/mL |
| 15 mg | 15 mg/mL | 7.5 mg/mL | 5 mg/mL | 3.75 mg/mL |
| 20 mg | 20 mg/mL | 10 mg/mL | 6.67 mg/mL | 5 mg/mL |
| 30 mg | 30 mg/mL | 15 mg/mL | 10 mg/mL | 7.5 mg/mL |
| 60 mg | 60 mg/mL | 30 mg/mL | 20 mg/mL | 15 mg/mL |
The ladder in units, by vial and water
Bold rows fit a 1 mL syringe across the whole ladder. Where a dose exceeds 100 units you need less water or a second injection.
5 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 5 mg/mL | 50 | 100 | - | - | - | - |
| 2 mL | 2.5 mg/mL | 100 | 200* | - | - | - | - |
| 3 mL | 1.67 mg/mL | 150* | 300* | - | - | - | - |
| 4 mL | 1.25 mg/mL | 200* | 400* | - | - | - | - |
10 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 10 mg/mL | 25 | 50 | 75 | 100 | - | - |
| 2 mL | 5 mg/mL | 50 | 100 | 150* | 200* | - | - |
| 3 mL | 3.33 mg/mL | 75 | 150* | 225* | 300* | - | - |
| 4 mL | 2.5 mg/mL | 100 | 200* | 300* | 400* | - | - |
15 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 15 mg/mL | 16.7 | 33.3 | 50 | 66.7 | 83.3 | 100 |
| 2 mL | 7.5 mg/mL | 33.3 | 66.7 | 100 | 133.3* | 166.7* | 200* |
| 3 mL | 5 mg/mL | 50 | 100 | 150* | 200* | 250* | 300* |
| 4 mL | 3.75 mg/mL | 66.7 | 133.3* | 200* | 266.7* | 333.3* | 400* |
20 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 20 mg/mL | 12.5 | 25 | 37.5 | 50 | 62.5 | 75 |
| 2 mL | 10 mg/mL | 25 | 50 | 75 | 100 | 125* | 150* |
| 3 mL | 6.67 mg/mL | 37.5 | 75 | 112.5* | 150* | 187.5* | 225* |
| 4 mL | 5 mg/mL | 50 | 100 | 150* | 200* | 250* | 300* |
30 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 30 mg/mL | 8.3 | 16.7 | 25 | 33.3 | 41.7 | 50 |
| 2 mL | 15 mg/mL | 16.7 | 33.3 | 50 | 66.7 | 83.3 | 100 |
| 3 mL | 10 mg/mL | 25 | 50 | 75 | 100 | 125* | 150* |
| 4 mL | 7.5 mg/mL | 33.3 | 66.7 | 100 | 133.3* | 166.7* | 200* |
60 mg vial
| Water | Conc. | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|---|
| 1 mL | 60 mg/mL | 4.2 | 8.3 | 12.5 | 16.7 | 20.8 | 25 |
| 2 mL | 30 mg/mL | 8.3 | 16.7 | 25 | 33.3 | 41.7 | 50 |
| 3 mL | 20 mg/mL | 12.5 | 25 | 37.5 | 50 | 62.5 | 75 |
| 4 mL | 15 mg/mL | 16.7 | 33.3 | 50 | 66.7 | 83.3 | 100 |
Units on a standard U-100 insulin syringe. * means more than 100 units, so more than one 1 mL syringe. A dash means the dose is larger than the vial.
Reading the chart
A 30 mg vial with 3 mL is the setup most people land on: 10 mg/mL, so the ladder runs 25, 50, 75, 100, 125 and 150 units. Fine up to 10 mg, then it outgrows the syringe. Reconstituting the same vial with 2 mL (15 mg/mL) brings 15 mg down to 100 units. A 5 mg vial is two 2.5 mg starting doses and nothing else, whatever the water. Write the water volume on the vial; the chart is useless a week later if you cannot remember which row you are on.

25 printable pages: dosing cards for the twelve most-used compounds at three water volumes, titration planners, a vial log, and five pages on what to do when it has already gone wrong.
Common questions
- How much bacteriostatic water do I add to a 30 mg tirzepatide vial?
- 3 mL is the common choice and gives 10 mg/mL, so 2.5 mg is 25 units and 10 mg is 100 units. If you are running 12.5 or 15 mg, 2 mL keeps those doses inside one syringe.
- How many units is 5 mg of tirzepatide?
- At 10 mg/mL (30 mg in 3 mL), 50 units. At 5 mg/mL (10 mg in 2 mL), 100 units. At 15 mg/mL (30 mg in 2 mL), 33.3 units. The vial and the water decide it, not the dose alone.
- Can I use the chart for a pen?
- No. Pens are a fixed concentration set by the manufacturer and are dosed by the pen's own dial. This chart is for lyophilised vials you reconstitute yourself.
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