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Tirzepatide reconstitution chart

Six vial sizes, four water volumes, the concentration of each combination and the units for every rung of the 2.5 to 15 mg ladder.

Tirzepatide vials come in 5, 10, 15, 20, 30 and 60 mg. The water you add sets the concentration, and the concentration sets how many units each rung of the 2.5 to 15 mg ladder needs. This chart gives every combination so you can pick a water volume that keeps your dose readable and inside one syringe.

Concentration for every vial and water volume

Vial1 mL2 mL3 mL4 mL
5 mg5 mg/mL2.5 mg/mL1.67 mg/mL1.25 mg/mL
10 mg10 mg/mL5 mg/mL3.33 mg/mL2.5 mg/mL
15 mg15 mg/mL7.5 mg/mL5 mg/mL3.75 mg/mL
20 mg20 mg/mL10 mg/mL6.67 mg/mL5 mg/mL
30 mg30 mg/mL15 mg/mL10 mg/mL7.5 mg/mL
60 mg60 mg/mL30 mg/mL20 mg/mL15 mg/mL

The ladder in units, by vial and water

Bold rows fit a 1 mL syringe across the whole ladder. Where a dose exceeds 100 units you need less water or a second injection.

5 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL5 mg/mL50100----
2 mL2.5 mg/mL100200*----
3 mL1.67 mg/mL150*300*----
4 mL1.25 mg/mL200*400*----

10 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL10 mg/mL255075100--
2 mL5 mg/mL50100150*200*--
3 mL3.33 mg/mL75150*225*300*--
4 mL2.5 mg/mL100200*300*400*--

15 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL15 mg/mL16.733.35066.783.3100
2 mL7.5 mg/mL33.366.7100133.3*166.7*200*
3 mL5 mg/mL50100150*200*250*300*
4 mL3.75 mg/mL66.7133.3*200*266.7*333.3*400*

20 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL20 mg/mL12.52537.55062.575
2 mL10 mg/mL255075100125*150*
3 mL6.67 mg/mL37.575112.5*150*187.5*225*
4 mL5 mg/mL50100150*200*250*300*

30 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL30 mg/mL8.316.72533.341.750
2 mL15 mg/mL16.733.35066.783.3100
3 mL10 mg/mL255075100125*150*
4 mL7.5 mg/mL33.366.7100133.3*166.7*200*

60 mg vial

WaterConc.2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
1 mL60 mg/mL4.28.312.516.720.825
2 mL30 mg/mL8.316.72533.341.750
3 mL20 mg/mL12.52537.55062.575
4 mL15 mg/mL16.733.35066.783.3100

Units on a standard U-100 insulin syringe. * means more than 100 units, so more than one 1 mL syringe. A dash means the dose is larger than the vial.

Reading the chart

A 30 mg vial with 3 mL is the setup most people land on: 10 mg/mL, so the ladder runs 25, 50, 75, 100, 125 and 150 units. Fine up to 10 mg, then it outgrows the syringe. Reconstituting the same vial with 2 mL (15 mg/mL) brings 15 mg down to 100 units. A 5 mg vial is two 2.5 mg starting doses and nothing else, whatever the water. Write the water volume on the vial; the chart is useless a week later if you cannot remember which row you are on.

Tirzepatide dosage chart: the 2.5 to 15 mg titration ladder converted to insulin syringe units
Tirzepatide dosage chart. Save or print this one, or download the full-size image. Open the live calculator to use your own numbers.
Live version: the tirzepatide dosage calculator. The titration schedule page runs the whole ladder with a vial count.

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Common questions

How much bacteriostatic water do I add to a 30 mg tirzepatide vial?
3 mL is the common choice and gives 10 mg/mL, so 2.5 mg is 25 units and 10 mg is 100 units. If you are running 12.5 or 15 mg, 2 mL keeps those doses inside one syringe.
How many units is 5 mg of tirzepatide?
At 10 mg/mL (30 mg in 3 mL), 50 units. At 5 mg/mL (10 mg in 2 mL), 100 units. At 15 mg/mL (30 mg in 2 mL), 33.3 units. The vial and the water decide it, not the dose alone.
Can I use the chart for a pen?
No. Pens are a fixed concentration set by the manufacturer and are dosed by the pen's own dial. This chart is for lyophilised vials you reconstitute yourself.

Related calculators and charts

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Every one of the 27 compound calculators, charts and tools: the full list.

Before you use these numbers This is a unit-conversion tool. It turns a vial strength and a water volume into a concentration, a draw volume and a syringe mark. It does not tell you what to take, whether to take it, or whether a compound is safe for you. Most compounds listed are sold for laboratory research and are not approved for human use. Nothing here is medical advice. Dosing decisions belong with a licensed clinician who knows your history. Always check the strength printed on your own vial rather than trusting a preset.